How does a single amino-acid substitution render the diphtheria toxin non-toxic?
https://pmc.ncbi.nlm.nih.gov/articles/PMC3325714/
I have only skimmed this paper, but the short answer seems to be that the two proteins fold into almost identical shapes, but CRM197 is more flexible at a crucial binding site.
Greg Egan
npub12c…gd38p
2026-09-22 05:37:56 UTC
in reply to nevent1q…fv8g
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2026-09-22 05:37:56 UTCEvent JSON
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