I think Amadeus knows this better than me, but is there something to be aware of when installing Audio apps as Flatpak? I believe native plugins are fine, but if you ever want to experiment with Windows plugins through Wine there is something to be aware of.
I know several people are really happy with Mint and you can install a lot of what you need from the build in App Store, so +1!
I use CachyOS (Arch based, gaming focused), here is my setup: https://mortenmosgaard.dk/how-i-setup-cachy-os-arch-linux-for-music-production/