nprofile1qy2hwumn8ghj7un9d3shjtnyd968gmewwp6kyqpqss7jcqsth4qpdx5kc8hu0zxs7870xmnrtz88wqtwvv2a20pmphhqqgztgk (nprofile…ztgk) Having two blocking mechanisms in parallel, but only some of the blocked connections showing up in Little Snitch caused quite a bit of confusion. It could happen that a connection was silently blocked via DNS, and users were wondering "why can’t I connect to that server, although LS doesn’t show this connection as blocked".
That said, if you really want to let Quad9 also filter your connections, you can create a custom DNS encryption setting that uses this filtering service.