I'm still on OpenSUSE on my laptop but I've been considering switching; lort knows since it's Tumbleweed they BOTH update frequently, and at least with Cachy the entire Arch wiki is applicable (if it's still up-to-date).
I even have VSTs working for stuff, licensed ones! (I don't think I've paid for any yet but some are licensed free via my Focusrite interface). Someone did a guide with scripts that can use a Bottles bottle (though because I'm running Bottles locally, not as a flatpak, I had to modify their script slightly) with a specific Wine runner for YABridge to run them. It's wild seeing the interface windows and their controls when adding as a rack in Carla. Mind, all of this isn't exactly Arch-specific stuff but like, it's cool as hell.
Really so far the Windows-only stuff I've been getting away with in a VM if I can't run it under Wine or Proton. Even current Affinity runs pretty damn solid under Wine. And sure, I can't use device firmware updaters in that, but I can via the Windows VM, temporarily attaching a device before removing once the update is done.