Nature (RSS/Atom feed) on Nostr: Persistent neuronal stress signalling underlies Angelman syndrome phenotypes Nature, ...

Persistent neuronal stress signalling underlies Angelman syndrome phenotypes

Nature, Published online: 21 October 2026; [doi:10.1038/s41586-026-11165-4][1]

Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS phenotypes.

[1]: https://www.nature.com/articles/s41586-026-11165-4


https://www.nature.com/articles/s41586-026-11165-4