Bone mineral density that declines during puberty blockade may not fully recover with cross-sex hormone treatment.
A cohort study of trans-identified people who had received puberty blockers and long-term cross sex hormones found that bone mineral density z-scores (which compare the patient with age- and sex-typical values) fell during puberty blockade, and did not fully recover following over a decade of cross-sex hormone treatment. This was especially the case for the lumbar spine of males receiving oestrogen.
It is also notable that, of the original 143 eligible participants, only 75 completed this research. Of those who left the cohort, 6 (4%) had discontinued cross-sex hormone treatment and 27 (19%) could not be reached. These figures are consistent with high loss to follow up in other studies of so-called “gender-affirming care.”
https://bird.makeup/users/statsforgender/statuses/2044025494148960420
Genspect
npub1cv…qdhaz
2026-04-14 12:13:26 UTC
Author Public Key
npub1cvjpy2yc2se9ghpph96twf09x467uzezj2lwxsewkgq4sqz5j3kslqdhazSeen on
wss://relay.momostr.pinkPublished at
2026-04-14 12:13:26 UTCEvent JSON
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"content": "Bone mineral density that declines during puberty blockade may not fully recover with cross-sex hormone treatment.\n\nA cohort study of trans-identified people who had received puberty blockers and long-term cross sex hormones found that bone mineral density z-scores (which compare the patient with age- and sex-typical values) fell during puberty blockade, and did not fully recover following over a decade of cross-sex hormone treatment. This was especially the case for the lumbar spine of males receiving oestrogen.\n\nIt is also notable that, of the original 143 eligible participants, only 75 completed this research. Of those who left the cohort, 6 (4%) had discontinued cross-sex hormone treatment and 27 (19%) could not be reached. These figures are consistent with high loss to follow up in other studies of so-called “gender-affirming care.”\nhttps://bird.makeup/users/statsforgender/statuses/2044025494148960420",
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