Nature (RSS/Atom feed) on Nostr: Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity Nature, ...

Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

Nature, Published online: 30 September 2026; [doi:10.1038/s41586-026-11087-1][1]

By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.

[1]: https://www.nature.com/articles/s41586-026-11087-1


https://www.nature.com/articles/s41586-026-11087-1