At same time one of the most hindering parts for me is, that I find it rly hard to build complex stuff with it that stays readable. I could never imagine writing a netscape like webbrowser in uxn.
There are great languages out there with which this might be feasible, but I feel like building actual compilers is a major undertaking esp. due to the quite complex/unconvential memory architecture of uxn (e.g. banks, zero page, stack based, ...)