An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors
Nature, Published online: 28 October 2026; [doi:10.1038/d41586-026-03288-5][1]
A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off a protein-degradation complex to allow cell proliferation to start, with implications for WEE1 inhibitors currently in trials for cancer treatments.
[1]: https://www.nature.com/articles/d41586-026-03288-5
https://www.nature.com/articles/d41586-026-03288-5
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npub1zf…4mpuv
2026-10-28 16:41:52 UTC
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npub1zfn2sces5k9rrqjxh9aplk5spd760rdk8hrsvul7er764vpl5jmsg4mpuvPublished at
2026-10-28 16:41:52 UTCEvent JSON
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"content": "An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors\n\nNature, Published online: 28 October 2026; [doi:10.1038/d41586-026-03288-5][1]\n\nA previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off a protein-degradation complex to allow cell proliferation to start, with implications for WEE1 inhibitors currently in trials for cancer treatments.\n\n[1]: https://www.nature.com/articles/d41586-026-03288-5\n\n\nhttps://www.nature.com/articles/d41586-026-03288-5",
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